Pauline McPeril in a small town.
Pauline McPeril was a syndicated strip that ran in the 1960’s. Pauline keeps getting into scrapes, and in these she (1) gets shrunk to doll size, (2) meets an inventor with a youth ray, and (3) wakes up as a giantess in a European town (sorry, not really for the last one but it’s a great scene anyway).
You can download them here on the Classic Comic Page.